Spikeshield. This blend was formulated to help manage and mitigate the numerous unwanted effects that the foremost promoted medical procedure of our times is creating, along with the purported effects the illness that ‘necessitated’ it*. The formula contains herbs that have either been proven in studies elsewhere to reduce the chance of certain manifestations of ill-health such as blood clots, or herbs that have been proven elsewhere to significantly decrease the ability of both naturally and synthetically occurring viral bodies to:Establish (dock)Replicate (produce other virions, replicate mutated DNA), andInteract (through binding the spike protein).It is a Spagyric Tincture blend of: 20% Fresh Pine Needle, 15% Fresh dandelion root and leaf, 10% Cat’s Claw, 10% Andrographis, 10% Schisandra, 10% Fennel Seed, 10% Fresh Stinging Nettle, 5% Fresh Orange Peel, 5% Horse Chestnut, and 5% HoneysuckleRecommended Minimum Dosage: 10 drops 2-3 times daily (can take more or less depending on intensity of need). 30ml last around 20-30 days 50ml lasts around 40-60 days 100ml lasts around 80-120 days Below you will find further detailing of these herbs and their properties that make them apt for this blend. This detailing is largely directly quoted information from peer-reviewed journal articles – with links to the complete articles. Pine Needles:Contain Suramin which further decreases the activities of a large number of enzymes involved in DNA and RNA synthesis and modification: DNA polymerases, RNA polymerases reverse transcriptase, telomerase, and enzymes involved in winding/ unwinding of DNA are inhibited by suramin, as well as histone- and chromatin-modifying enzymes like chromobox proteins Suramin also showed inhibitory effects against components of the coagulation cascade. https://www.researchgate.net/publication/277348748_Content_Analysis_of_Shikimic_Acid_in_the_Masson_Pine_Needles_and_Antiplatelet-aggregating_ActivityThe results showed that the shikimic acid content in Masson pine needles, Oriental arborvitae leafy twigs and Star anise was 5.71%, 1.74% and 8.95%, respectively. Shikimic acid, when separated by HPLC, exhibited a dose-dependent inhibitory effect on platelet aggregation [clotting] induced by adenosine diphosphate and collagen in rabbits. Dandelion:The researchers used high molecular weight compounds taken from a water-based dandelion extract and put them to the test in human HEK293-hACE2 kidney and A549-hACE2-TMPRSS2 lung cells. The dandelion blocked the protein-to-protein interactions between the S1 sub unit of the spike protein and the human ACE2 cell surface receptor. This effect was also true against the spike protein mutations from the predominant variants in circulation, including the United Kingdom (B.1.1.7), South African (B.1.351) and Brazilian (P.1) variant.A German university study found that the common dandelion (Taraxacum officinale) can block spike proteins from binding to the ACE2 cell surface receptors in human lung and kidney cells. The water-based dandelion extract, taken from the plant’s dried leaves, was effective against spike protein D614 and a host of mutant strains, including D614G, N501Y, K417N and E484K.The dandelion extract stopped SARS-CoV-2 spike pseudotyped lentivirus particles from attaching to lung cells and stopped an inflammatory process called interleukin-6 secretion. https://www.biorxiv.org/content/10.1101/2021.03.19.435959v1.article-infoDandelion also contains shikimate Cat’s Claw:U. tomentosa showed an inhibition of 92.7% of SARS-CoV-2 at 25.0 μg/mL (p < 0.0001) by plaque reduction assay on Vero E6 cells. In addition, U. tomentosa induced a reduction of 98.6% (p=0.02) and 92.7% (p=0.03) in the CPE caused by SARS-CoV-2 on Vero E6 cells at 25 μg/mL and 12.5 μg/mL, respectively…. These results showed that U. tomentosa, known as cat's claw, has an antiviral effect against SARS-CoV-2, which was observed as a reduction in the viral titer and CPE after 48 h of treatment on Vero E6 cells. Therefore, we hypothesized that U. tomentosa stem bark could be promising in the development of new therapeutic strategies against SARS-CoV-2.Andrographis:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212536/This paper evaluates the compound Andrographolide from Andrographis paniculata as a potential inhibitor of the main protease of SARS-COV-2 (Mpro) through in silico studies such as molecular docking, target analysis, toxicity prediction and ADME prediction. Andrographolide was docked successfully in the binding site of SARS-CoV-2 Mprohttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8056600/SARS-CoV-2 at 25TCID50 was able to reach the maximal infectivity of 95% in Calu-3 cells. Postinfection treatment of A. paniculata and andrographolide in SARS-CoV-2-infected Calu-3 cells significantly inhibited the production of infectious virions with an IC50 of 0.036 μg/mL and 0.034 μM, respectively, as determined by the plaque assay. The cytotoxicity profile developed over the cell line representatives of major organs, including liver (HepG2 and imHC), kidney (HK-2), intestine (Caco-2), lung (Calu-3), and brain (SH-SY5Y), showed a CC50 of >100 μg/mL for A. paniculate... In conclusion, this study provided experimental evidence in favor of A. paniculata and andrographolide for further development as a monotherapy or in combination with other effective drugs against SARS-CoV-2 infection.Andrographis is also anti-allergenic.Andrographolide is also well known for its broad-spectrum antiviral properties.24 Studies showed andrographolide is effective against influenza A,43 hepatitis C virus… ,40 HIV,45 hepatitis B virus,46 Herpes simplex virus 1,47 Epstein–Barr virus,48… This study showed that both A. paniculata extract and its active component andrographolide had a potent inhibitory effect against SARS-CoV-2. In comparison to our previous study,30A. paniculata extract and andrographolide exhibited the equivalent IC50 against SARS-CoV-2 infection to remdesivir30 (Table 1). It has been suggested that people who have been vaccinated will be more likely to develop AIDS/HIV.The Thai government approved Andrographis for the treatment of Covid. Shizandra berry: Potent immunomodulator, antithrombotic, blood cleanser, antimutagenic. Contains Shikimic acid: Fennel Seed: These are also an excellent source of shikimate or shikimic acid.See additional info section for details on the other ingredients. This blend was designed to significantly increase one’s chances of maintaining good health in the face of certain medical interventions and viral occourences, though it comes with no guarantee of any particular outcome, consumers purchase and use with their own discretion and discernment.
*Before purchase please see full disclaimer at bottom of page.
Spikeshield
*The most common allergic ingredients in vaccines come from eggs, gelatin, yeast, formaldehyde and latex.
mRNA vaccines contain polyethylene glycol (PEG) all of which can cause allergic reactions*Stinging nettles:
Are anti-allergenic, containing high levels of antihistamines, also contains quercetin which is in some popular protocols for defense against spike proteins.
https://pubmed.ncbi.nlm.nih.gov/33398633/Angiotensin-converting enzyme 2 (ACE-2), a human receptor that facilitates entry of SARS-CoV-2, serves as a prominent target for drug discovery. In the present study, we have applied the bioinformatics approach for screening of a series of bioactive chemical compounds from Himalayan stinging nettle (Urtica dioica) as potent inhibitors of ACE-2 receptor (PDB ID: 1R4L). Based on the highest binding affinity, 23 compounds were shortlisted as a lead molecule using molecular docking analysis. Among them, β-sitosterol was found with the highest binding affinity - 12.2 kcal/mol and stable interactions with the amino acid residues present on the active site of the ACE-2 receptor. Similarly, luteoxanthin and violaxanthin followed by rutin also displayed stronger binding efficiency. We propose these compounds as potential lead candidates for the development of target-specific therapeutic drugs against COVID-19.
Orange Peel:
Together, our results suggest that 4′-acetamidechalcones inhibit the interaction of the virus with host cells through binding to ACE2 or SPIKE protein, probably generating a steric impediment. In addition, chalcones have an affinity for important enzymes in post-translational processes, interfering with viral replication.https://www.sciencedirect.com/science/article/pii/S0006291X20322518
https://draxe.com/nutrition/hesperidin/
Horse Chestnut:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271932/
aescin isolated from the horse chestnut tree also inhibited SARS-CoV replication at non-toxic concentrations [22,100].
Honeysuckle:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271932/
The TCM’s Jinchai consists of plant species such as Lonicera japonica and Bupleurum chinense among others, that prevent the coronavirus entry into cells and inhibit general viral replication as well as the specific 3CLpro-mediated replication [29].
Generally, the viral loads observed in patients correlate with the severity of symptoms and mortality. The multisystem inflammatory syndrome, known as cytokine storm, occurring in many COVID-19 patients, is caused by an uncontrolled replication of the virus resulting in an over-activation of the immune system, including high levels of pro-inflammatory cytokines, i.e., interleukin-1β (IL-1β) and TNFα [105]… Similarly, one study observed that chlorogenic acid, luteoloside, quercetin, and other compounds in L. japonica, exhibited anti-inflammatory, antiviral, antibacterial, and antioxidant activity and enhanced immune response. It is known that one of the main possible anti-SARS mechanisms is decreasing the expression of inflammatory mediators such as the transforming growth factor-beta (TNF-β) and IL-1β [49].
